NasoPass™ is our innovative intranasal delivery platform engineered to improve the administration of biological therapeutics, including vaccines, antibodies, proteins and peptides, directly to the nasal mucosa. By providing a more efficient route, NasoPass™ maximizes drug availability at the site of action.
For vaccination, NasoPass™ rapidly achieves high local concentrations in the nasopharynx, inducing secretory IgA and neutralizing antibodies to prevent initial infection and establish the respiratory tract’s first line of defense. It also enhances vaccine penetration across the nasal mucosa, ultimately triggering systemic IgG memory responses for broad, long-lasting protection.
For respiratory disease treatment, conventional antibody therapies require injections to achieve therapeutic levels because of their large molecular size. With NasoPass™ the same biologics are delivered directly to the disease site, substantially reducing the required dose while matching or exceeding the efficacy of injectable formulations and minimizing unnecessary systemic exposure and side effects.
NasoPass™ is ideally suited to the treatment of chronic rhinosinusitis, allergic rhinitis and upper respiratory tract infections. Its non-invasive, needle-free design is easy to use and ensures patient comfort, while delivering and sustaining therapeutic concentrations directly at the target site.
Antibody drugs like IL‑4Rα inhibitors are large molecules (approximately 150 kilodaltons), which makes them difficult to deliver efficiently by the nasal route. Currently, no antibody therapies have been approved for intranasal delivery.
NasoPass™ has demonstrated a significant breakthrough in this area—delivering more than twice the therapeutic efficacy compared to subcutaneous injection, using only one-twelfth of the original dose. This suggests that NasoPass™ could offer a new path for effective and lower-dose antibody treatments through a simpler and more targeted route.
Our nasal vaccine approach generates a more comprehensive and powerful immune response. Data shows NasoPass™ leads to an 99% increase in nasal IgA concentration, providing robust first-line mucosal protection, and a 239% increase in blood IgG concentration, enhancing long-lasting systemic immunity.